Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
As NOS1AP is overexpressed in the cortex of patients with SCZ and negatively regulates NMDAR signaling, we subsequently examined whether treatment with antipsychotics or NMDAR agonists can reverse the detrimental effects of NOS1AP overexpression in vitro as previously reported by our group.
|
29601869 |
2018 |
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
NOS1AP mRNA and serum levels were significantly elevated in SCZ patients (p<0.001; p<0.001) compared with healthy control.
|
29100974 |
2018 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
An increasing body of evidence is pointing to the significant roles of NOS1AP in excitotoxic neuronal damage, traumatic nervous system injury, bipolar disorder, and schizophrenia.
|
27237129 |
2016 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Amongst the most promising candidate molecules for schizophrenia are neuronal nitric oxide (NO) synthase (NOS-I, also known as nNOS) and its adapter protein NOS1AP (previously named CAPON).
|
26861996 |
2016 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Results suggest that NOS1AP variants are associated with various forms of depression in schizophrenia and are more prevalent in males.
|
26384012 |
2015 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
The NOS1-NOS1AP PDZ interface may thus well constitute a novel target for small molecules in at least some forms of schizophrenia.
|
24220657 |
2014 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
The NOS1-NOS1AP PDZ interface may thus well constitute a novel target for small molecules in at least some forms of schizophrenia.
|
24220657 |
2014 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
NOS1AP is encoded by a gene recently associated with sudden cardiac death, diabetes-associated complications, and schizophrenia (Arking et al., 2006; Becker et al., 2008; Brzustowicz, 2008; Lehtinen et al., 2008).
|
23658158 |
2013 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.
|
23212062 |
2012 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results were similar after adjusting for the NOS1AP risk genotype (adjusted OR=3.57, 95% CI=1.32, 9.65) and for maternal or paternal history of schizophrenia (adjusted ORs=3.27, 95% CI=1.45, 7.38; 4.38, 95% CI=1.61, 11.91, respectively).
|
20541371 |
2010 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
We compared MRI volumetric data between individuals with 1q21-q23 linked familial schizophrenia associated with NOS1AP and their first and second degree unaffected relatives.
|
20638248 |
2010 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the coding sequence of NOS1AP in a large population (n = 280), including patients with schizophrenia (n = 72), ASD (n = 81) or OCD (n = 34), and in healthy volunteers controlled for the absence of personal or familial history of psychiatric disorders (n = 93).
|
20602773 |
2010 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
We compared MRI volumetric data between individuals with 1q21-q23 linked familial schizophrenia associated with NOS1AP and their first and second degree unaffected relatives.
|
20638248 |
2010 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our findings are consistent with a role for NOS1AP in susceptibility to schizophrenia, especially for the 'negative syndrome' of the disorder.
|
19077434 |
2009 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
LHGDN |
Our findings are consistent with a role for NOS1AP in susceptibility to schizophrenia, especially for the 'negative syndrome' of the disorder.
|
19077434 |
2009 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Of these, four contained or neighboured genes associated with schizophrenia (NOS1AP/UHMK1, ATF2, NSF and PIK3C3).
|
19451863 |
2009 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Identification of a schizophrenia-associated functional noncoding variant in NOS1AP.
|
19255043 |
2009 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results identified no single marker nor haplotype associated with schizophrenia, which did not suggest that CAPON was a susceptible site in the Chinese Han population, or it appeared unlikely that the CAPON played a major role in the aetiology of schizophrenia.
|
18430503 |
2008 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The finding of allelic association with markers in the UHMK1 gene might help explain why it has not been possible, despite great effort, to satisfactorily confirm previously reported associations between schizophrenia and the genes RGS4 and NOS1AP/CAPON.
|
18414510 |
2008 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Our results identified no single marker nor haplotype associated with schizophrenia, which did not suggest that CAPON was a susceptible site in the Chinese Han population, or it appeared unlikely that the CAPON played a major role in the aetiology of schizophrenia.
|
18430503 |
2008 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this review, I present the evidence supporting NOS1AP as a schizophrenia susceptibility gene, with a focus on explaining the strengths and weaknesses of the evidence obtained from each type of study that has been conducted.
|
18474209 |
2008 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
In this review, I present the evidence supporting NOS1AP as a schizophrenia susceptibility gene, with a focus on explaining the strengths and weaknesses of the evidence obtained from each type of study that has been conducted.
|
18474209 |
2008 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Four of these 9 "risk ROHs" contained or neighbored genes associated with SCZ (NOS1AP, ATF2, NSF, and PIK3C3).
|
18077426 |
2007 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We detected positive allelic association after the eighth marker was genotyped and found that three microsatellite markers (p = .011, p = .014, p = .049) and two SNPs (p = .004, p = .043) localized in the 700 kb region between the RGS4 and CAPON genes, within the UHMK1 gene, were associated with schizophrenia.
|
16978587 |
2007 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
The present finding weakens the evidence that mutations or variation in the CAPON gene are causing genetic susceptibility to schizophrenia in European populations.
|
16202394 |
2006 |